MyBioSource.com's LILRB2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The LILRB2 Antibody was generated using LILRB2 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Subunit Structure: Binds PTPN6 when phosphorylated. Binds FCGR1A.
Post-translational Modifications: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Similarity: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases